TRANSCRIPTOME AND DNA METHYLOME ANALYSIS IN A MOUSE MODEL OF DIET-INDUCED OBESITY PREDICTS INCREASED RISK OF COLORECTAL CANCER

Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer

Colorectal cancer (CRC) tends to occur at older age; however, CRC incidence rates have been rising sharply among young age groups.The increasing prevalence of obesity is recognized as a major risk, yet the mechanistic underpinnings remain poorly understood.Using a diet-induced obesity mouse model, we identified obesity-associated molecular changes

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Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis.

Endocannabinoids and some phytocannabinoids bind to CB1 and CB2 cannabinoid receptors, transient receptor potential vanilloid one (TRPV1) receptor and the orphan G protein receptor fifty-five (GPR55).Studies using C57BL/10 and C57BL/6 (Cnr2 (tm1Zim)) CB2 cannabinoid receptor knockout mice Concealers have demonstrated an immune-augmenting effect in

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